NEW YORK (AP) — Donald Trump is set to lambaste Democratic rival Hillary Clinton as a failed secretary of state out of step with Americans on trade and immigration.

Trump’s address Wednesday morning at his hotel in New York’s SoHo neighborhood marks his official opening salvo against Clinton in the general election. It comes as the presumptive Republican nominee faces growing questions about his readiness not just for the presidency, but for the campaign he will need to run to get there.

Trump’s campaign is hoping the speech can quiet those concerns and rally Republicans around their shared opposition to Clinton. The billionaire businessman plans to focus in particular on Clinton’s tenure at the State Department, arguing that her foreign policy is in part responsible for the creation of the Islamic State militant group.

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