BOSTON (AP) — More than 6,200 cyclists will ride in this weekend’s Pan-Mass Challenge, a two-day, 192-mile ride across Massachusetts to raise money for the Dana-Farber Cancer Institute.

The goal this year is to raise $48 million for cancer research and patient care. If that amount is raised, it would bring the PMC’s 38-year contribution to Dana-Farber to more than $595 million.

The ride kicks off Saturday in Sturbridge, continues east through Massachusetts and ends at the finish line in Provincetown on Sunday.

Riders commit to raise between $500 and $7,800. Funds raised by the PMC account for more than 52 percent of the annual revenue of the Jimmy Fund, Dana-Farber’s fundraising arm.

Many of the riders and volunteers are cancer survivors or current patients.

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